Circumventing Antineoplastic Drug Resistance: When Tumor Cells Just Say “No” to Drugs
نویسنده
چکیده
Antineoplastic drug resistance represents a specialized case of drug tolerance since cells most responsive to therapy are destroyed. Clinically, drug resistance may be observed at the onset of therapy or is acquired later by a tumor cell population over time due to a combination of spontaneous genetic mutations and selection by cytotoxic chemotherapy. Numerous mechanisms of drug resistance have been elucidated from in vitro studies but their relevance to clinical drug resistance has only recently begun to be appreciated. Newly described drug resistance mechanisms in tumor cells
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